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Updated: Jul 6, 2026

Synthesis and Reaction Chemistry of Nanosize Monosodium Titanate
Published on: February 23, 2016
Determining the solution state orientation of a Ti enolate via stable isotope labeling, NMR spectroscopy, and
David B Kimball1, Ryszard Michalczyk, Eddie Moody
1NIH Stable Isotope Resource, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA.
Abstract:
Our group has used Ti-promoted aldol additions with an oxazolidineselone as the chiral auxiliary with much success. In these reactions, the Se atom in the auxiliary both promotes stereospecific addition as well as reports on, through the use of 77Se NMR spectroscopy, the ratio of diastereomers produced and the geometry of intermediates as the reaction proceeds. Through stable isotope labeling and NMR spectroscopy, we are able to experimentally observe a Ti enolate in solution and gain insight into its structure and reactivity. Results from molecular modeling calculations are also presented for comparison with NMR data.
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