Related Experiment Video
Updated: Aug 1, 2026

Setting Limits on Supersymmetry Using Simplified Models
Published on: November 16, 2013
Model uncertainty and choices made by modelers: lessons learned from the International Atomic Energy Agency model
Igor Linkov1, Dmitriy Burmistrov
1ICF Consulting, Lexington, MA 02421, USA. ilinkov@icfconsulting.com
Abstract:
The treatment of uncertainties associated with modeling and risk assessment has recently attracted significant attention. The methodology and guidance for dealing with parameter uncertainty have been fairly well developed and quantitative tools such as Monte Carlo modeling are often recommended. However, the issue of model uncertainty is still rarely addressed in practical applications of risk assessment. The use of several alternative models to derive a range of model outputs or risks is one of a few available techniques. This article addresses the often-overlooked issue of what we call "modeler uncertainty," i.e., difference in problem formulation, model implementation, and parameter selection originating from subjective interpretation of the problem at hand. This study uses results from the Fruit Working Group, which was created under the International Atomic Energy Agency (IAEA) BIOMASS program (BIOsphere Modeling and ASSessment). Model-model and model-data intercomparisons reviewed in this study were conducted by the working group for a total of three different scenarios. The greatest uncertainty was found to result from modelers' interpretation of scenarios and approximations made by modelers. In scenarios that were unclear for modelers, the initial differences in model predictions were as high as seven orders of magnitude. Only after several meetings and discussions about specific assumptions did the differences in predictions by various models merge. Our study shows that parameter uncertainty (as evaluated by a probabilistic Monte Carlo assessment) may have contributed over one order of magnitude to the overall modeling uncertainty. The final model predictions ranged between one and three orders of magnitude, depending on the specific scenario. This study illustrates the importance of problem formulation and implementation of an analytic-deliberative process in risk characterization.
Related Concept Videos
Molecular Models
Propagation of Uncertainty from Systematic Error
Multicompartment Models: Overview
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
Mechanistic Models: Overview of Compartment Models
Modeling and Similitude
Typical Model Studies

