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Neural crest cells: a model for invasive behavior.

Richard P Tucker1

  • 1Department of Cell Biology and Human Anatomy, School of Medicine, University of California at Davis, 1 Shields Avenue, Davis, CA 95616, USA. rptucker@ucdavis.edu

The International Journal of Biochemistry & Cell Biology
|December 4, 2003
PubMed
Summary
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Neural crest cells, crucial for peripheral nervous system and pigment cell development, undergo epithelial to mesenchymal transition (EMT) for migration. Understanding their induction and migration is key to preventing birth defects.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Genetics

Background:

  • Neural crest cells are multipotent embryonic cells.
  • They differentiate into diverse cell types, including neurons, glia, and pigment cells.
  • Their development is critical for craniofacial, cardiac, and peripheral nervous system formation.

Purpose of the Study:

  • To review recent advances in neural crest cell induction and migration.
  • To highlight the molecular mechanisms regulating neural crest cell development.
  • To emphasize the importance of avian and amphibian models in this research.

Main Methods:

  • In vivo studies using antisense techniques.
  • In vitro studies of cell migration and invasive behavior.
  • Analysis of gain and loss-of-function constructs for key regulatory genes.

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Main Results:

  • Neural crest cells undergo epithelial to mesenchymal transition (EMT) for migration.
  • Specific transcription factors (Snail, Slug, FoxD3) regulate delamination.
  • Invasive properties of neural crest cells resemble tumor cell motility.

Conclusions:

  • Disruptions in neural crest cell survival or differentiation lead to birth defects.
  • Understanding neural crest cell migration is vital for developmental biology.
  • Avian and amphibian models provide crucial insights into neural crest development.