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Immunologic parameters in Down's syndrome.

P F Jacobs, N M Burdash, J P Manos

    Annals of Clinical and Laboratory Science
    |January 1, 1978
    PubMed
    Summary
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    Children with Down syndrome (DS) show higher respiratory infection rates. While most immune factors appear normal, decreased immunoglobulin M (IgM) levels in DS patients suggest a potential link to the syndrome itself.

    Area of Science:

    • Immunology
    • Genetics
    • Pediatrics

    Background:

    • Children with Down syndrome (DS) exhibit increased susceptibility to respiratory infections.
    • Immune system dysregulation may underlie this heightened vulnerability.

    Purpose of the Study:

    • To establish normal immune values in DS patients.
    • To investigate humoral immune abnormalities associated with Down syndrome.

    Main Methods:

    • Compared immunoglobulin levels, complement components, viral antibodies, and hepatitis B surface antigen in DS patients versus matched controls.
    • Assessed both inpatient and outpatient populations.

    Main Results:

    • No significant abnormalities found in most immunoglobulins or complement levels.

    Related Experiment Videos

  • A notable decrease in immunoglobulin M (IgM) was observed in both inpatient and outpatient DS groups.
  • Hepatitis B surface antigen was present only in institutionalized DS patients, independent of other immune markers.
  • IgE-mediated atopic sensitivity did not explain the observed symptomatology.

    • Conclusions:

    • Decreased IgM levels may be associated with Down syndrome.
    • Upper respiratory infections in DS are not primarily linked to generally low immunoglobulin or complement levels.
    • Further research into IgM's role in DS immune function is warranted.