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HLA class I nucleotide sequences, 1992.

J Zemmour1, P Parham

  • 1Department of Cell Biology, Stanford University, California 94305-5400.

Human Immunology
|August 1, 1992
PubMed
Summary
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This compilation presents Human Leukocyte Antigen (HLA) class I exon 2-4 sequences from established literature. It incorporates amendments based on author contact to ensure accuracy in the HLA sequence alignment.

Area of Science:

  • Immunogenetics
  • Molecular Biology
  • Human Leukocyte Antigen (HLA) System

Background:

  • The Human Leukocyte Antigen (HLA) system is crucial for immune response.
  • Accurate HLA sequence data is essential for transplantation and disease association studies.
  • Previous compilations of HLA sequences have been published in 1989, 1990, and 1991.

Purpose of the Study:

  • To compile and present updated Human Leukocyte Antigen (HLA) class I sequences.
  • To focus on exons 2-4 due to an increased number of available sequences.
  • To ensure the accuracy of the compiled HLA sequences through verification with original authors.

Main Methods:

  • Sequences were sourced from published literature: "Nomenclature for Factors of the HLA System, 1991", "1990", and "1989".

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  • Only sequences for exons 2-4 were included in this compilation.
  • Discrepancies in reported sequences were addressed by contacting original authors for amendments.
  • Sequence alignments use hyphens (-) for nucleotide identity, periods (.) for unavailable sequences, and gaps for allele variation.

    • Main Results:

    • A compilation of Human Leukocyte Antigen (HLA) class I sequences, focusing on exons 2-4, has been generated.
    • Incorporation of amendments based on direct author communication enhances sequence accuracy.
    • The alignment methodology accounts for nucleotide identity, missing data, and variations in amino acid numbering.

    Conclusions:

    • This updated compilation provides a valuable resource for researchers studying the Human Leukocyte Antigen (HLA) system.
    • The rigorous approach to verifying and amending sequences ensures a high degree of accuracy.
    • Continuous updates and contributions are welcomed to maintain the integrity of this HLA sequence database.