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Analysis of left ventricular function from gated first-pass and multiple gated equilibrium acquisitions
P Vainio1, J Jurvelin, J Kuikka
1Department of Clinical Physiology and Nuclear Medicine, University Hospital, Kuopio, Finland.
International Journal of Cardiac Imaging
|January 1, 1992
Summary
99mTechnetium-sestamibi (Tc-99m) accurately assesses left ventricular ejection fraction (LVEF) using first-pass radionuclide angiography. This new agent provides precise LVEF measurements comparable to the established multiple gated equilibrium radionuclide ventriculography (MUGA) technique.
Area of Science:
- Nuclear Cardiology
- Radiopharmaceuticals
- Cardiovascular Imaging
Background:
- 201Thallium has limitations for myocardial perfusion imaging.
- 99mTechnetium-sestamibi offers physical advantages for myocardial perfusion imaging.
- 99mTechnetium-sestamibi can assess ventricular function via first-pass radionuclide angiography (FPRNA).
Purpose of the Study:
- To compare gated list mode first-pass acquisition with 99mTc-sestamibi (FP-MIBI) to multiple gated equilibrium radionuclide ventriculography (MUGA) for determining global left ventricular ejection fraction (LVEF).
Main Methods:
- 20 patients underwent stress-rest perfusion imaging.
- Resting FPRNA was performed using 99mTc-sestamibi.
- Reference data were acquired using the MUGA technique with 99mTc-labelled red blood cells within a week.
Main Results:
- A strong linear correlation was found between FP LVEF and MUGA LVEF (r = 0.974, p < 0.01).
- Diastolic and systolic timing and velocity parameters showed lower correlations between the two methods.
- Global LVEF was precisely measured by 99mTc-sestamibi FPRNA.
Conclusions:
- Global LVEF can be accurately measured using 99mTc-sestamibi first-pass radionuclide angiography.
- 99mTc-sestamibi is a viable alternative to the MUGA technique for LVEF assessment.
- Further evaluation of diastolic and systolic parameters using 99mTc-sestamibi may be warranted.