Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Contested conceptions: PKU in the postwar discourse on reproduction.

Diane B Paul1

  • 1Department of Political Science, University of Massachusetts, Boston, MA, USA.

Medicina Nei Secoli
|December 3, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

50 Years Ago in The Journal of Pediatrics: Maternal Phenylketonuria: Implications for Growth and Development.

The Journal of pediatrics·2018
Same author

Eugenics Redux: "Reproductive Benefit" as a Rationale for Newborn Screening.

The Hastings Center report·2018
Same author

50 Years Ago in The Journal of Pediatrics: Variability in the Manifestations of Phenylketonuria/Transient Hyperphenylalaninemia.

The Journal of pediatrics·2018
Same author

50 Years Ago in The Journal of Pediatrics: Conference on Treatment of Phenylketonuria.

The Journal of pediatrics·2016
Same author

50 Years Ago in TheJournal ofPediatrics: Evaluation of the Effects of Terminating the Diet in Phenylketonuria.

The Journal of pediatrics·2016
Same author

50 Years Ago in TheJournal ofPediatrics: Legislation and Advances in Medical Knowledge-Acceleration or Inhibition?

The Journal of pediatrics·2016
Same journal

INVISIBLE WOMEN IRELAND AND THE FIGHT TO ACCESS SAFE AND LEGAL ABORTION.

Medicina nei secoli·2018
Same journal

BLOOD DONATION IN OAXACA CITY (MEXICO) MEDICO-ANTHROPOLOGICAL REFLECTIONS.

Medicina nei secoli·2018
Same journal

[[General Practitioners and Public Health in Italy: Medical Office of Doctor Sgandurra from Farindola (Abruzzi, Central Italy)].]

Medicina nei secoli·2017
Same journal

[The Ram's Heads on the Pompejan Quadri Valve Speculum (Bljouiez. Jackson 291: Naples Arch. Mus. 113264)1].

Medicina nei secoli·2017
Same journal

[[Abortion, Stigma and Conscientious Objection: Experiences and Opinions of Gynecologists in Italy and Catalonia].]

Medicina nei secoli·2017
Same journal

[[Italian 194 Law, Conscientious Objection and the European Disapproval].]

Medicina nei secoli·2017
See all related articles

Phenylketonuria (PKU) screening allowed affected individuals to reproduce, but led to a second-generation effect of severe damage in their offspring. This highlights evolving perspectives on genetics and reproductive choices.

Area of Science:

  • Medical Genetics
  • Reproductive Health
  • Public Health Policy

Background:

  • The essay examines shifting views on genetics and reproduction using the case of Phenylketonuria (PKU).
  • Early Phenylketonuria (PKU) diagnosis and therapy in the 1960s enabled affected individuals to reach adulthood and reproduce.
  • Lionel Penrose's work in the 1940s critiqued eugenics using the Phenylketonuria (PKU) case.

Observation:

  • A "second-generation" effect emerged by the 1980s due to Phenylketonuria (PKU) screening.
  • Infants born to women treated for Phenylketonuria (PKU) experienced severe developmental damage.
  • This outcome contrasted with the initial success of newborn screening for Phenylketonuria (PKU).

Findings:

  • Newborn screening for Phenylketonuria (PKU) had unintended negative consequences across generations.

Related Experiment Videos

  • The Phenylketonuria (PKU) case illustrates the complex interplay between genetic conditions, medical interventions, and reproductive behavior.
  • Evolving understanding of Phenylketonuria (PKU) influenced public health strategies and ethical considerations.

    • Implications:

    • The Phenylketonuria (PKU) case study underscores the need for long-term monitoring of genetic screening programs.
    • It highlights the ethical challenges in balancing individual reproductive autonomy with public health concerns.
    • The historical trajectory of Phenylketonuria (PKU) management reflects changing societal views on genetics, disability, and eugenics.