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Published on: June 27, 2025
[Ambulatory pulse pressure and left ventricular hypertrophy in patients with essential hypertension]
Yang Cao1, Shui-ping Zhao, Lin Luo
1Department of Cardiovasology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Insights
Ambulatory pulse pressure and aortic root dimension are key factors contributing to left ventricular hypertrophy (LVH) in essential hypertension. Monitoring these metrics can help identify patients at risk for LVH.
Area of Science:
- Cardiology
- Hypertension Research
- Diagnostic Imaging
Context:
- Essential hypertension is a prevalent cardiovascular condition.
- Left ventricular hypertrophy (LVH) is a significant predictor of cardiovascular events.
- Ambulatory blood pressure monitoring and echocardiography are crucial diagnostic tools.
Purpose:
- To investigate the association between ambulatory pulse pressure, aortic root dimension (AOD), and left ventricular hypertrophy (LVH).
- To identify specific parameters of ambulatory pulse pressure that correlate with LVH in hypertensive patients.
Summary:
- This study analyzed 107 essential hypertensive patients using 24-hour ambulatory blood pressure monitoring and echocardiography.
- Patients with LVH showed significant differences in 24-hour, daytime, and nighttime pulse pressure, as well as AOD, compared to those without LVH.
- Nighttime pulse pressure and AOD were identified as significant predictors of left ventricular mass index (LVMI).
Impact:
- Findings highlight the importance of pulse pressure and AOD in the development of LVH.
- This research can inform clinical practice for risk stratification and management of essential hypertension.
- Early identification of these factors may lead to interventions aimed at preventing LVH progression and associated complications.
Objective:
To evaluate the relationship between the left ventricular hypertrophy (LVH) and the ambulatory pulse pressure and aortic root dimension (AOD) in essential hypertensive patients.
Methods:
We monitored the 24-hour ambulatory blood pressure and applied echocardiography in 107 essential hypertensive patients. Using the left ventricular mass index (LVMI) as an index in evaluating LVH, the patients were divided into 2 groups: 29 cases in the LVH group and 78 in the non-LVH group.
Results:
The average levels of 24-hour pulse pressure, daytime pulse pressure, nighttime pulse pressure and AOD were significantly different between patients with LVH and without LVH (P < 0.05). Multiple stepwise regression analysis showed that the changes in nighttime pulse pressure and AOD were closely related to LVMI (P < 0.001).
Conclusion:
The pulse pressure and AOD are important factors leading to LVH in patients with essential hypertension.
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