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Efficient synthesis of substituted vinyl ethers using the Julia olefination

Simon Surprenant1, Wing Yan Chan, Carl Berthelette

  • 1Department of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, P.O. Box 1005, Pointe-Claire/Dorval, Québec, Canada, H9R 4P8.

Organic Letters
|December 5, 2003
PubMed
Summary

This study introduces a new Julia olefination method using alpha-alkoxy sulfones to create vinyl ethers. The reaction is efficient, with yields ranging from 46-90%, and the starting materials are easily prepared.

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