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Updated: Aug 29, 2026

Direct Drug Delivery to Kidney via the Renal Artery
Published on: April 17, 2021
A site-specific polymeric drug carrier for renal disease treatment
1Department of Biomedical Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, 565-8565, Osaka, Japan. kishida@ri.ncvc.go.jp
Abstract:
A well-designed polymeric carrier for site-specific drug delivery in the treatment of renal disease has been reported recently. Approximately 80% of the water-soluble polymer poly(vinylpyrrolidone-co-dimethyl maleic anhydride selectively accumulated in the kidney of mice 24 h after intravenous injection. The detailed mechanism of such selective accumulation is not clear but an energy-dependent process, other than endocytosis, might be involved in the uptake of the polymer. This study is the first to report active targeting using a synthetic polymeric drug carrier.
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