Related Experiment Videos
[Malignant pheochromocytoma responsive to multimodal therapy: a case report]
Masatoshi Mukai1, Nobufumi Kanno, Masahiro Nakagawa
1Department of Urology, Osaka Rosai Hospital.
Hinyokika Kiyo. Acta Urologica Japonica
|December 6, 2003
Summary
This case study details a patient with malignant pheochromocytoma who developed a kidney tumor and bone metastasis. Successful treatment involved surgery, radiation, and chemotherapy, leading to significant symptom improvement.
Area of Science:
- Oncology
- Endocrinology
- Radiology
Background:
- A 62-year-old male with a history of adrenal pheochromocytoma presented with a suspected right renal tumor.
- Initial diagnosis was aided by ultrasound, computed tomography, and magnetic resonance imaging.
Observation:
- A 10 cm mass was identified in the upper pole of the right kidney.
- 131I-MIBG scintigraphy confirmed radioisotope uptake, indicative of tumor presence.
- The patient later developed paraplegia due to Th2 bone metastasis.
Findings:
- Histological examination confirmed the renal mass as malignant pheochromocytoma.
- The patient underwent right nephrectomy and subsegmental hepatectomy.
- Radiation therapy and cyclophosphamide, vincristine, dacarbazine (CVD) chemotherapy were administered for metastatic disease.
Implications:
- The case highlights the potential for pheochromocytoma to metastasize to the kidney and bone.
- Multimodal treatment including surgery, radiation, and chemotherapy can effectively manage malignant pheochromocytoma with metastasis.
- This demonstrates a successful therapeutic strategy for a rare presentation of pheochromocytoma.