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Updated: Aug 29, 2026
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
Published on: March 24, 2022
Two-dimensional measurement of photon beam attenuation by the treatment couch and immobilization devices using an
Sandra C Vieira1, Robert S J P Kaatee, Maarten L P Dirkx
1Department of Radiation Oncology, Division of Clinical Physics, Erasmus MC/Daniel den Hoed Cancer Center, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands. s.vieira@erasmusmc.nl
Abstract:
In our institution, an individualized dosimetric quality assurance protocol for intensity modulated radiotherapy (IMRT) is being implemented. This protocol includes dosimetric measurements with a fluoroscopic electronic portal imaging device (EPID) for all IMRT fields while the patient is being irradiated. For some of the first patients enrolled in this protocol, significant beam attenuation by (carbon fiber) components of the treatment couch was observed. To study this beam attenuation in two-dimensional, EPID images were also acquired in absence of the patient, both with and without treatment couch and immobilization devices, as positioned during treatment. For treatments of head and neck cancer patients with a 6 MV photon beam, attenuation of up to 15% was detected. These findings led to the development of new tools and procedures for planning and treatment delivery to avoid underdosages in the tumor.
