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Structure-activity relationship studies of illudins: analogues possessing a spiro-cyclobutane ring
Trevor C McMorris1, Qiang Cong, Michael J Kelner
1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0506, USA. tmcmorris@ucsd.edu
The Journal of Organic Chemistry
|December 6, 2003
Abstract:
Bicyclic and tricyclic analogues of anticancer sesquiterpene illudin S have been synthesized. These contain a spiro-cyclobutane instead of spiro-cyclopropane structure. The cytotoxicity of the former is less than that of the corresponding cyclopropane-containing compounds.