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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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Updated: Jul 18, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

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Published on: September 27, 2017

Atopic dermatitis and the atopic march.

Jonathan M Spergel1, Amy S Paller

  • 1Division of Allergy and Immunology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

The Journal of Allergy and Clinical Immunology
|December 6, 2003
PubMed
Summary

Atopic dermatitis (AD) affects infants and children, negatively impacting quality of life and leading to other allergic conditions like asthma. Early intervention may help slow this progression, known as the atopic march.

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Area of Science:

  • Pediatric Dermatology
  • Allergology
  • Immunology

Background:

  • Atopic dermatitis (AD) is a prevalent skin disorder in infants and children, with increasing incidence globally.
  • AD significantly impacts patient and family quality of life, causing sleep disturbances and financial burdens.
  • The condition often initiates the 'atopic march,' a progression to other allergic diseases.

Purpose of the Study:

  • To review the characteristics, impact, and progression of atopic dermatitis.
  • To explore the concept of the atopic march and its underlying mechanisms.
  • To discuss potential early intervention strategies for atopic dermatitis.

Main Methods:

  • Review of longitudinal studies on atopic dermatitis progression.
  • Analysis of epidemiological data on atopic dermatitis prevalence.
  • Examination of immunological theories regarding epicutaneous sensitization and T cell migration.

Main Results:

  • Approximately 50% of AD patients develop asthma, and 66% develop allergic rhinitis, especially with severe AD.
  • Epicutaneous sensitization is hypothesized to drive the atopic march via T cell migration to airways.
  • Preliminary studies suggest oral antihistamines may slow the atopic march.

Conclusions:

  • Atopic dermatitis is a critical early manifestation of allergic disease with significant long-term implications.
  • Understanding the atopic march is crucial for developing effective prevention and treatment strategies.
  • Early intervention, potentially with oral antihistamines, shows promise in mitigating the progression of atopic diseases.