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[Flurbiprofen: therapeutic alternative in nephritic colic]
M Julián Mora1, J Extramiana, F J Navarro
1Servicio de Urología, Hospital de Móstoles, Madrid, España.
Archivos Espanoles De Urologia
|October 1, 1992
Summary
This study compared dipyrone with hyoscine N-butylbromide versus flurbiprofen for renoureteric colic pain. Both treatments provided similar pain relief, with comparable side effects and need for additional analgesia.
Area of Science:
- Pharmacology
- Urology
- Pain Management
Background:
- Renoureteric colic causes severe pain.
- Effective analgesia is crucial for patient comfort and management.
- Comparing different analgesic options is essential for optimizing treatment.
Purpose of the Study:
- To compare the therapeutic efficacy of dipyrone plus hyoscine N-butylbromide against flurbiprofen in patients with renoureteric colic.
- To assess pain intensity, relief, and status following single intramuscular doses of the two analgesic regimens.
Main Methods:
- A double-blind, randomized study involving 52 patients with renoureteric colic.
- Patients received either dipyrone (2 gm) plus hyoscine N-butylbromide (20 mg) or flurbiprofen (150 mg) intramuscularly.
- Pain assessment was conducted for one hour post-administration.
Main Results:
- Both treatments demonstrated similar analgesic effects, with 76.9% of patients experiencing pain remission.
- No significant differences were found in pain latency or intensity at various time points (5, 10, 30, 60 minutes).
- Additional analgesia was required in 34.6% of the dipyrone group and 26.9% of the flurbiprofen group, a non-significant difference.
Conclusions:
- Dipyrone with hyoscine N-butylbromide and flurbiprofen are similarly effective for managing renoureteric colic pain.
- Both drug regimens were well-tolerated, with local adverse effects like pain being the most common.
- Further research may explore long-term efficacy and different administration routes.