Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Pathophysiologic cardiovascular changes in stress and depression].

L Spieker1, G Noll

  • 1Universitätsspital Zürich.

Therapeutische Umschau. Revue Therapeutique
|December 13, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endothelial function and sympathetic nervous system activity in patients with Takotsubo syndrome.

International journal of cardiology·2016
Same author

[New AHA and ACC guidelines on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk : Statement of the D•A•CH Society for Prevention of Cardiovascular Diseases, the Austrian Atherosclerosis Society and the Working Group on Lipids and Atherosclerosis (AGLA) of the Swiss Society for Cardiology].

Der Internist·2014
Same author

The antiproliferative effect of pinostrobin on human umbilical vein endothelial cells (HUVEC).

European review for medical and pharmacological sciences·2013
Same author

Management of hypertension in patients with diabetes mellitus and metabolic syndrome in Swiss primary care.

International journal of clinical practice·2012
Same author

[Effect of paracetamol (acetaminophen) on blood pressure in patients with coronary heart disease].

Praxis·2012
Same author

Acute effect of nitroglycerin on cyclosporine-induced hypertension after cardiac transplantation.

Swiss medical weekly·2010
Same journal

[Multimodal Cardiac Imaging: New Developments for Clinical Practice].

Therapeutische Umschau. Revue therapeutique·2026
Same journal

[Coronary angiography: From cardiac catheterization to advanced interventional cardiovascular imaging].

Therapeutische Umschau. Revue therapeutique·2026
Same journal

[Athlete's heart: role of cardiac imaging in the prevention of sudden cardiac death].

Therapeutische Umschau. Revue therapeutique·2026
Same journal

[Multimodal imaging in cardiac amyloidosis and cardiac sarcoidosis].

Therapeutische Umschau. Revue therapeutique·2026
Same journal

[Inflammatory Heart Disease: The Role of Multimodality Cardiac Imaging in Myocarditis and Pericarditis].

Therapeutische Umschau. Revue therapeutique·2026
Same journal

State-of-the-Art Cardiac Imaging

Therapeutische Umschau. Revue therapeutique·2026
See all related articles

Mental stress, including emotions like anger and grief, can trigger heart attacks. Psychological distress significantly worsens cardiovascular outcomes by impacting the nervous system and endothelial function.

Area of Science:

  • Cardiology
  • Psychosomatic Medicine
  • Vascular Biology

Context:

  • Mental stress is increasingly recognized as a significant risk factor for cardiovascular disease.
  • Emotions such as fear, anger, and grief can precipitate acute cardiac events like myocardial ischemia and infarction.
  • The sympathetic nervous system plays a critical role in mediating cardiovascular responses to stress.

Purpose:

  • To explore the mechanisms by which mental stress impacts cardiovascular regulation and contributes to morbidity and mortality.
  • To investigate the link between mental stress, endothelial dysfunction, and the development of atherosclerotic vascular disease.
  • To elucidate the role of psychological factors, including hostility and depression, in cardiovascular risk.

Summary:

  • Mental stress activates the sympathetic nervous system, leading to vasoconstriction, tachycardia, and arrhythmia, thereby increasing cardiovascular risk.

Related Experiment Videos

  • Acute mental stress induces prolonged endothelial dysfunction in healthy individuals, a process potentially mediated by endothelin A receptors, linking stress to atherosclerosis.
  • Depression is associated with hypercortisolemia and a prothrombotic state, contributing to elevated cardiovascular risk in affected patients.

    • Impact:

    • Findings highlight the importance of managing psychological stress in cardiovascular disease prevention and treatment.
    • Identifies potential therapeutic targets, such as endothelin A receptors, for mitigating stress-induced cardiovascular harm.
    • Emphasizes the need for integrated care approaches addressing both psychological and cardiovascular health.