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Flow-tissue interaction with compliance mismatch in a model stented artery
Angela Tortoriello1, Gianni Pedrizzetti
1Dipartimento di Ingegneria e Fisica dell'Ambiente, Università degli Studi della Basilicata, C.da Macchia Romana, 85100 Potenza, Italy.
Journal of Biomechanics
|December 16, 2003
Summary
Endovascular prostheses can cause blood clots due to altered blood flow dynamics. This study reveals how prosthesis-induced changes in vessel compliance and diameter create harmful wall shear stresses, increasing thrombogenic risk.
Area of Science:
- Biomedical Engineering
- Fluid Dynamics
- Medical Device Design
Background:
- Endovascular prostheses can cause thrombogenic effects due to blood-prosthesis interaction.
- Prostheses induce compliance mismatch and vessel expansion, altering wall shear stresses.
Purpose of the Study:
- To numerically investigate fluid dynamics in stented elastic vessels.
- To evaluate the impact of compliance mismatch and lumen variation on wall shear stress.
Main Methods:
- Utilized a perturbative approach to model fluid-tissue interaction.
- Validated the approach with a one-dimensional model.
- Applied the method to an axisymmetric model of a stented vessel.
Main Results:
- Compliance mismatch generates intense negative wall shear stresses in stented segments.
- Rapid wall shear stress variations occur at stent ends.
- These effects are amplified by a small increase in vessel lumen.
Conclusions:
- Prosthesis-induced hemodynamic changes contribute to thrombogenic risk.
- Understanding wall shear stress distribution is crucial for stent design.
- Minimizing compliance mismatch and lumen expansion may reduce adverse effects.