Pathological and functional amyloid formation orchestrated by the secretory pathway
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Updated: Aug 29, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
Mary E Huff1, William E Balch, Jeffery W Kelly
1The Scripps Research Institute, Departments of Chemistry, The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, BCC265, La Jolla, CA 92037, USA.
Abstract:
Amyloidogenesis has historically been associated with pathology in a class of neurodegenerative diseases known as amyloid diseases. Recent studies have shown that proteolysis by furin during secretion initiates both variant gelsolin amyloidogenesis, associated with the disease familial amyloidosis of Finnish type, and Pmel17 fiber formation, which is necessary for the functional biogenesis of melanosomes. Proteolysis combined with organelle-dependent environment changes orchestrate amyloidogenesis associated with both pathological processes and a functional pathway.
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