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Populations at high risk for prostate cancer
Kisseng Hsieh1, Peter C Albertsen
1Division of Urology, Department of Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-3955, USA.
The Urologic Clinics of North America
|December 19, 2003
Summary
Certain men face a higher risk of aggressive prostate cancer due to family history, specific biopsy findings, or race. Early screening for these high-risk individuals is a logical approach.
Area of Science:
- Oncology
- Urology
- Genetics
Background:
- Prostate cancer is typically slow-growing and affects older men.
- A subset of patients is at high risk for early, aggressive disease.
- Risk factors include family history, specific histologic features (PIN, ASAP), and race.
Purpose of the Study:
- To identify high-risk groups for prostate cancer.
- To emphasize the importance of screening for at-risk populations.
- To discuss the potential benefits of aggressive treatment in high-risk cases.
Main Methods:
- Review of existing literature on prostate cancer risk factors.
- Analysis of demographic data comparing prostate cancer incidence across racial groups.
- Evaluation of histological findings in initial biopsies.
Main Results:
- Black American men exhibit a significantly higher risk of prostate cancer compared to white and Asian men.
- Family history and specific histological findings like PIN (prostatic intraepithelial neoplasia) and ASAP (asymptomatic prostatitis) are indicators of increased risk.
- Genetic and environmental factors likely contribute to racial disparities in prostate cancer risk.
Conclusions:
- Screening men at increased risk for prostate cancer is a recommended strategy.
- Early detection and aggressive treatment may improve outcomes for high-risk patients.
- Further research into genetic and environmental factors influencing prostate cancer risk is warranted.