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Updated: Aug 29, 2026

In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse
Published on: October 6, 2023
Selective thyroid hormone receptor modulators
Hikari A I Yoshihara1, Thomas S Scanlan
1Departments of Pharmaceutical Chemistry and Cellular & Molecular Pharmacology, University of California-San Francisco, San Francisco, CA 94143-2280, USA.
Abstract:
Thyroid hormone regulates many important processes in vertebrates. Analysis of the symptoms that accompany hypo- and hyperthyroidism, the most common disorders of the thyroid, suggests that there are certain desirable biological effects brought about by an excess or deficiency of thyroid hormone, and that selective thyroid hormone receptor modulators (STRMs) would be potentially useful therapeutic agents. This review will provide an introduction to thyroid hormone biology, and will discuss the chemistry and pharmacology of the first generation STRMs.
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