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Related Experiment Videos

[Non specific bronchial hyperreactivity in infants].

L M Guirau1, D Solé, C K Naspitz

  • 1Universidade Federal de São Paulo, Escola Paulista de Medicina.

Jornal De Pediatria
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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The relationship between second-hand smoke and wheezing in infants from Córdoba, Argentina.

Allergologia et immunopathologia·2019

The methacholine bronchoprovocation test effectively detects bronchial hyperreactivity in wheezing infants. This safe and well-tolerated test helps diagnose respiratory issues in young children.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Clinical Allergy

Context:

  • Wheezing infants often present diagnostic challenges.
  • Bronchial hyperreactivity (BHR) is a key feature in pediatric respiratory conditions.
  • Early identification of BHR is crucial for timely intervention.

Purpose:

  • To assess BHR in wheezing infants (WB) versus normal control infants (C).
  • To evaluate the efficacy and safety of the methacholine bronchoprovocation test (BPT) in infants.
  • To determine the provocative concentration of methacholine causing wheezing (PCW) in both groups.

Summary:

  • The study utilized BPT with methacholine (M) on 51 WB and 20 C under two years old.
  • Pulmonary auscultation monitored for wheezing to determine PCW.

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  • WB showed significantly lower PCW values (2.3 mg/ml) compared to controls (9.2 mg/ml), with 41% of WB responding positively at 2.5 mg/ml.

    • Impact:

    • BPT using PCW is a viable method for diagnosing BHR in young children.
    • The test is well-tolerated, safe, and easy to administer.
    • Further research can elucidate the clinical significance of PCW values.