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Pathogenic enterococci: new developments in the 21st century
P M Tendolkar1, A S Baghdayan, N Shankar
1Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA.
Cellular and Molecular Life Sciences : CMLS
|December 20, 2003
Summary
Enterococci bacteria, once considered harmless gut microbes, are now recognized as significant causes of severe hospital-acquired infections due to their extensive antibiotic resistance. Recent research highlights advances in understanding their genomes and pathogenicity.
Area of Science:
- Microbiology
- Infectious Diseases
- Genomics
Background:
- Enterococci are Gram-positive commensal bacteria found in the human and animal digestive tracts.
- They are increasingly recognized as a cause of serious nosocomial infections.
- Enterococci possess significant intrinsic and acquired antibiotic resistance.
Purpose of the Study:
- To review key advancements in enterococcal research since the year 2000.
- To focus on new insights into enterococcal genomes and pathogenicity.
Main Methods:
- Literature review of scientific publications from the 21st century.
- Analysis of studies focusing on enterococcal genomics and virulence factors.
Main Results:
- Significant progress has been made in understanding the genetic makeup of enterococci.
- New information has emerged regarding the mechanisms of enterococcal pathogenicity.
- The dual role of enterococci as commensals and pathogens is better understood.
Conclusions:
- Genomic and pathogenicity studies have revolutionized our understanding of enterococci.
- Advances since 2000 provide critical insights into combating enterococcal infections.