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[Allergy skin testing after topical anesthesia].

F P Ferrari1, N A Rosário Filho, A V Schmidt

  • 1Departmento de Pediatria, HC, UFPr, Curitaba, PR.

Jornal De Pediatria
|July 1, 1996
PubMed
Summary
This summary is machine-generated.

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EMLA (eutectic mixture of local anesthetics) cream can significantly alter immediate skin test reactions. This topical anesthetic should not be used before allergy skin testing due to its interference with results.

Area of Science:

  • Dermatology
  • Allergology
  • Pharmacology

Context:

  • Immediate skin reactions are key indicators in diagnosing atopic diseases.
  • Skin prick testing is a common diagnostic tool for allergies.
  • EMLA cream is a local anesthetic used to mitigate discomfort during medical procedures.

Purpose:

  • To investigate the effects of EMLA cream on immediate skin test reactions induced by allergens and histamine.
  • To evaluate how EMLA cream influences the wheal and flare response, reaction onset, and local temperature changes.

Summary:

  • Application of EMLA cream for one hour significantly delayed the onset of skin reactions to both allergens and histamine.
  • EMLA cream reduced the wheal diameter and local temperature variations in response to both allergen and histamine challenges.

Related Experiment Videos

  • The findings suggest that EMLA cream interferes with histamine's action, thereby diminishing immediate skin test responses.

    • Impact:

    • EMLA cream's ability to suppress immediate skin test reactions indicates it can interfere with diagnostic accuracy.
    • Results strongly advise against using EMLA cream for pain reduction during allergy skin testing.
    • This study highlights the importance of avoiding confounding factors in allergy diagnostics.