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Is there a significant gene dose effect in the primed lymphocyte test?
Pig lymphocytes typed for products of the MHC were primed in vitro against allogeneic lymphocytes. When rechallenged with a panel of different cells, specific 'typing' responses were distinguishable which were not obscured by high non-specific responses or by a restimulator gene dose effect. A gene additive effect was observed in both primary MLR and in the primed lymphocyte test (PLT).
Pig lymphocytes typed for products of the MHC were primed in vitro against allogeneic lymphocytes. When rechallenged with a panel of different cells, specific 'typing' responses were distinguishable which were not obscured by high non-specific responses or by a restimulator gene dose effect. A gene additive effect was observed in both primary MLR and in the primed lymphocyte test (PLT).