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Menstrual induction with mifepristone and misoprostol
Bilian Xiao1, Helena von Hertzen, Heng Zhao
1National Research Institute for Family Planning, No. 12 Da Hui Si, 100081, Beijing, People's Republic of China. xiaobl@public.bta.net.cn
Contraception
|December 31, 2003
Summary
Medical menstrual induction using mifepristone and misoprostol effectively induced uterine evacuation in most women with delayed menses. This regimen demonstrated a high success rate for both pregnant and non-pregnant individuals, with mild side effects.
Area of Science:
- Reproductive Medicine
- Gynecology
- Pharmacology
Background:
- Menstrual induction is an early uterine evacuation procedure for delayed menses.
- Mechanical aspiration is common, but medical options like mifepristone and prostaglandin analogues are being explored.
- A pilot study suggested potential efficacy for this medical regimen.
Purpose of the Study:
- To evaluate the efficacy and side effects of mifepristone followed by misoprostol for menstrual induction.
- To assess the outcome in women with a menstrual delay of up to 7 days.
Main Methods:
- A total of 720 women were recruited.
- Participants received 150 mg mifepristone, followed 2 days later by 0.4 mg misoprostol vaginally.
- Pregnancy status was retrospectively confirmed via human chorionic gonadotropin (hCG) levels.
Main Results:
- Uterine evacuation was induced in 97.4% of pregnant and 97.8% of non-pregnant women.
- Complete abortion occurred in 92.5% of pregnant women.
- The overall expected outcome was achieved in 95.8% of all treated women, with mild side effects.
Conclusions:
- The medical regimen of mifepristone and misoprostol is effective for menstrual induction.
- A continuing pregnancy rate of 5.1% warrants further investigation and comparison with mechanical aspiration.
- Further research is needed to compare medical regimens with vacuum aspiration for safety, efficacy, and acceptability.