Related Experiment Videos
Binding of imidazole-derived nucleosides to a CG base pair
Maria G M Purwanto1, Klaus Weisz
1Institut für Chemie und Biochemie, Ernst-Moritz-Arndt-Universität Greifswald, Soldmannstrasse 16, D-17489 Greifswald, Germany.
The Journal of Organic Chemistry
|January 3, 2004
Abstract:
Novel imidazole nucleosides with substituents of different flexibility were studied for their binding to a CG Watson-Crick base pair by (1)H NMR spectroscopy in an aprotic solvent. Thermodynamic data as determined by titration experiments at different temperatures reveal the influence of the substituent on the enthalpy and entropy of complex formation and thus on the strength of binding.