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Updated: Jul 11, 2026

Studying DNA Looping by Single-Molecule FRET
Published on: June 28, 2014
Impact of loop length and duplex extensions on the design of hybrid-type G-quadruplexes
Jagannath Jana1, Yoanes Maria Vianney1, Klaus Weisz1
1Institut für Biochemie, Universität Greifswald, Felix-Hausdorff Str. 4, Greifswald D-17489, Germany. weisz@uni-greifswald.de.
Abstract:
A G-rich core sequence G3-TCA-G3-T1,2-G3-T1,2-G3 can be designed to fold into a parallel or into two different (3+1) hybrid-type G-quadruplexes, among them an elusive topology with one lateral followed by two propeller loops. Favored folds can be rationalized based on the number of intervening thymidines and on additional complementary flanking sequences.
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