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[The different levels of prednisolone in perilymph after local and systemic treatment]
Jiping Su1, G Bachmann, Anzhou Tang
1Department of Otolaryngology, First Affiliated Hospital, Guangxi Medical University, Nanning 530021.
Objective:
The present study was to analysis the pharmacokinetics of prednisolone-21-hydrogensuccinate in the perilymph after local and systemic application.
Method:
On the local application, 5% prednisolone-21-hydrogensuccinate was directly applied into the round window niche under the microscopy. On the systemic application, the drug (60 mg/kg) was used intraperitoneal. Perilymphatic samples were obtained after variable periods of application. Levels of prednisolone-21-hydrogensuccinate in perilymph were measured by using HPLC.
Result:
The highest level of the drug was on (952.3 +/- 382.7) mg/L after 180 min. And remained on (18.72 +/- 16.97) mg/L after 960 min in the local application groups. In the systemic application group, the highest level of the drug was on(14.71 +/- 7.05) mg/L after 150 min.
Conclusion:
The results demonstrate that high levels and long time remain of prednisolone-21-hydrogensuccinate in perilymph are achievable by a single dose local application into the round window niche.
