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Related Experiment Videos

Indomethacin-responsive headache syndromes.

David W Dodick1

  • 1Department of Neurology, Mayo Medical School, Mayo Clinic, 13400 East Shea Blvd, Scottsdale, AZ 85259, USA. dodick.david@mayo.edu

Current Pain and Headache Reports
|January 21, 2004
PubMed
Summary

Indomethacin-responsive headache syndromes, including hemicranias and ice-pick headaches, show a distinct response to indomethacin. These rare headache disorders are often overlooked but can be effectively managed with this specific medication.

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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Indomethacin-responsive headache syndromes are a unique class of primary headaches.
  • They exhibit a specific and potent response to indomethacin, unlike other NSAIDs or headache treatments.
  • These conditions may be underdiagnosed due to their distinct characteristics.

Purpose of the Study:

  • To define and categorize indomethacin-responsive headache syndromes.
  • To highlight their clinical differentiation and response patterns to indomethacin.
  • To increase awareness of these potentially common, yet overlooked, headache disorders.

Main Methods:

  • Clinical differentiation of headache syndromes based on response to indomethacin.
  • Categorization into trigeminal-autonomic cephalgias, valsalva-induced headaches, and primary stabbing headache.
  • Review of literature and clinical observations regarding indomethacin efficacy.

Main Results:

  • Indomethacin-responsive headaches include specific trigeminal-autonomic cephalgias, valsalva-induced headaches, and primary stabbing headache (ice-pick headache).
  • Paroxysmal and continuous hemicranias show an absolute response to indomethacin.
  • Valsalva-induced and ice-pick headaches demonstrate a dramatic but less consistent response. Hypnic headache may also respond.

Conclusions:

  • Indomethacin is a key diagnostic and therapeutic tool for specific headache syndromes.
  • Recognizing these syndromes is crucial for accurate diagnosis and effective treatment.
  • Further research may elucidate the mechanisms behind indomethacin's efficacy in these conditions.

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