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Updated: Aug 29, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
Published on: May 3, 2018
Cellular substrates of p34(cdc2) and its companion cyclin-dependent kinases
1Swiss Institute for Experimental Cancer Research (ISREC), 155 Chemin des Boveresses, CH-1066 Epalinges, Switzerland.
Abstract:
Cyclin-dependent kinase (cdks) are key components of the engine that drives the cell proliferation cycle in all eukaryotes. These kinases are related to p34(cdc2) and associate with regulatory subunits belonging to the cyclin family. To understand how cdks promote cell cycle progression, it will be important to identify their physiological substrates and to determine how phosphorylation influences the functions of these substrates. This article discusses recent progress as well as some of the problems related to the quest for cdk substrates.
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M cyclin...