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First synthesis of an amythiamicin pyridine cluster
Mark C Bagley1, James W Dale, Robert L Jenkins
1School of Chemistry, Cardiff University, PO Box 912, Cardiff, UKCF10 3TB. bagleymc@cf.ac.uk
Chemical Communications (Cambridge, England)
|January 23, 2004
Abstract:
The pyridine-containing central domain of the amythiamicin group of thiopeptide antibiotics is prepared in protected form in 9 steps, 93%ee and 18% overall yield from (S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]thiazole-4-carboxylic acid by Michael addition-cyclodehydration of a 2-(2-thiazolyl)enamine and 1-(2-thiazolyl)propynone.