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Related Experiment Videos

Interindividual variability in the hemispheric organization for speech.

N Tzourio-Mazoyer1, G Josse, F Crivello

  • 1Groupe d'Imagerie Neurofonctionnelle (GIN), UMR 6095 CNRS, CEA, Universités de Caen et Paris 5, 14074 Cedex, Caen, France. tzourio@cyceron.fr

Neuroimage
|January 27, 2004
PubMed
Summary

This study explored brain lateralization during language tasks. Most subjects showed typical left-hemisphere dominance for speech, but some exhibited atypical patterns, suggesting flexible brain organization.

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Large-scale plurimodal networks common to listening to, producing and reading word lists: an fMRI study combining task-induced activation and intrinsic connectivity in 144 right-handers.

Brain structure & function·2019

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Psycholinguistics

Background:

  • Investigating hemispheric specialization is crucial for understanding brain function.
  • Language processing involves complex interactions between brain regions.
  • Individual differences in handedness may correlate with language representation.

Purpose of the Study:

  • To investigate hemispheric specialization during speech comprehension and production.
  • To compare language representation in right- and left-handed subjects.
  • To identify typical and atypical patterns of language lateralization.

Main Methods:

  • Positron Emission Tomography (PET) activation study.
  • Measured normalized regional cerebral blood flow (NrCBF) during listening (Story) and verb generation (Gener) tasks.

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  • Calculated functional asymmetry indices (FAI) in anatomical regions of interest (AROIs).

    • Main Results:

    • Predominantly leftward FAIs were observed in most subjects during both tasks.
    • Larger leftward asymmetries were noted during verb generation (Gener) compared to speech comprehension (Story).
    • Six subjects (including five left-handers) displayed atypical language representation, with one showing right-hemisphere dominance.

    Conclusions:

    • Language tasks induce a hemispheric reconfiguration, establishing a "language mode".
    • Typical language lateralization involves left-hemisphere dominance in specific brain regions.
    • Atypical subjects may exhibit distinct hemispheric regulation or regional specialization patterns.