Pediatric brain tumors

Brain tumors in children vary with regard to histology, location, gender distribution, and age of onset. The past several decades have witnessed substantial improvements in the diagnosis and treatment. As a result, the number of long-term survivors also has increased continuously. Recent advances in neuroimaging facilitate tumor localization and mapping of brain function by noninvasive techniques and are becoming important in preoperative assessment for brain tumors. Surgery remains the mainstay of treatment of many tumor types. A role for chemotherapy is emerging, particularly for nonresectable tumors and in infants, for whom the adverse effects of radiation therapy are severe. Despite the improved treatments and prognostic data, however, many long-term survivors experience significant neurocognitive and developmental deficits.