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Published on: November 22, 2011
[Urinary disturbance due to HTLV-1 associated myelopathy]
H Sakiyama1, K Nishi, H Kikukawa
1Department of Urology, Kumamoto University Medical School.
Nihon Hinyokika Gakkai Zasshi. the Japanese Journal of Urology
|December 1, 1992
Summary
Human T-cell lymphotropic virus type 1 associated myelopathy (HAM) frequently causes urinary dysfunction. Most patients experience irritative and obstructive voiding symptoms, often preceding gait issues, due to spinal cord damage.
Area of Science:
- Neurology
- Urology
- Virology
Context:
- Human T-cell lymphotropic virus type 1 (HTLV-1) infection can lead to HTLV-1 associated myelopathy (HAM).
- Urinary disturbances are common but often underreported complaints in HAM patients.
- Understanding the spectrum of urinary symptoms is crucial for comprehensive patient care.
Purpose:
- To investigate the prevalence and characteristics of urinary symptoms in untreated HAM patients.
- To evaluate urodynamic findings in HAM patients with urinary complaints.
- To explore the relationship between spinal cord lesions and lower urinary tract dysfunction in HAM.
Summary:
- Nineteen of twenty-one (89%) untreated HAM patients reported urinary symptoms like dysuria, pollakisuria, incontinence, or urgency.
- Urodynamic studies revealed overactive bladder in 66% and underactive/incontractile bladder in 15% of cases.
- Detrusor sphincter dyssynergia (DSD) was frequently observed, suggesting neurological damage to the spinal cord's lateral column.
Impact:
- Highlights the high incidence of urinary dysfunction in HAM, emphasizing its clinical significance.
- Provides insights into the urodynamic patterns associated with HAM-related neurological damage.
- Suggests that urinary symptoms can be an early indicator of HAM, potentially aiding in earlier diagnosis and management.
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