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First carbamates conversion to amides by simple alkyl group transfer from trialkylalanes
Laurent El Kaim1, Laurence Grimaud, Anabelle Lee
1Laboratoire Chimie et procédés, Ecole Nationale Supérieure de Techniques Avancées, 32 Bd Victor, 75739 Paris Cedex 15, France. elkaim@ensta.fr
Organic Letters
|January 30, 2004
Abstract:
[reaction: see text] N-Monosubstituted carbamates are cleanly converted to amides under treatment with trialkylaluminum. This reaction involves an aluminum-assisted internal delivery of alkyl groups. It can be applied to new and mild protecting group strategies for alcohols.