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Monitoring the Reductive and Oxidative Half-Reactions of a Flavin-Dependent Monooxygenase using Stopped-Flow Spectrophotometry
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Model systems for flavoenzyme activity: interplay of hydrogen bonding and aromatic stacking in cofactor redox

Mark Gray1, Allan J Goodman, Joseph B Carroll

  • 1Department of Chemistry, University of Massachusetts, Amherst 01003, USA.

Organic Letters
|January 30, 2004
PubMed
Summary

A new model system reveals how aromatic stacking and hydrogen bonding influence flavin derivative binding. The study highlights that both pi-stacking and hydrogen bonding units are crucial for receptor affinity in oxidized and radical anion flavin forms.

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