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Familial exudative vitreoretinopathy (FEVR). Clinical profile and management
Dhananjay Shukla1, Jatinder Singh, G Sudheer
1Retina Vitreous Service, Aravind Eye Hospital & Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India. daksh@aravind.org
Indian Journal of Ophthalmology
|January 31, 2004
Summary
Familial Exudative Vitreoretinopathy (FEVR) is more common than previously thought. Early diagnosis and intervention are crucial for managing this condition and preventing vision loss, especially in affected families.
Area of Science:
- Ophthalmology
- Genetics
- Retinal Diseases
Background:
- Familial Exudative Vitreoretinopathy (FEVR) is a genetic disorder affecting retinal vascular development.
- It can lead to severe vision impairment and blindness if not managed promptly.
Purpose of the Study:
- To describe the diagnosis and management of FEVR in an Indian population.
- To highlight the importance of early detection and intervention.
Main Methods:
- A prospective case series of 38 FEVR patients and 23 family members.
- Diagnosis confirmed via clinical examination, fluorescein angiography, and family screening.
- Treatment included prophylactic photocoagulation/cryotherapy or surgery based on disease severity.
Main Results:
- Mean patient age was 23.6 years; 116 eyes evaluated.
- Common findings included peripheral avascular zones (41.4%), new vessels (6.9%), and retinal detachments (30.1%).
- Prophylactic treatment maintained stable vision in 34 eyes; 85.7% reattachment rate and 50% improved BCVA in surgically treated RDs.
Conclusions:
- FEVR is likely underdiagnosed and more prevalent than reported.
- Lifelong monitoring and early intervention are vital due to disease progression and potential for late exacerbations.
- High suspicion, family screening, and early prophylaxis are recommended to prevent avoidable blindness.