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Updated: Jul 31, 2026
09:04
A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
Vascular endothelial growth factor expression in pituitary adenomas
S Fukui1, H Nawashiro, N Otani
1Department of Neurosurgery, National Defense Medical College, Tokorozawa, Saitama, Japan.
Acta Neurochirurgica. Supplement
|February 3, 2004
Summary
Vascular endothelial growth factor (VEGF) expression is linked to cystic formation in pituitary adenomas. This study suggests VEGF may influence the development of these cystic components in tumors.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Pituitary adenomas frequently exhibit cystic components and hemorrhage.
- Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis and vascular permeability.
Purpose of the Study:
- To investigate the expression of VEGF in pituitary adenomas.
- To determine the correlation between VEGF expression and clinicopathological features, including cystic formation and hemorrhage.
Main Methods:
- Immunohistochemical examination of VEGF expression in 48 pituitary adenoma samples.
- Correlation analysis with MR imaging findings (cystic component, hemorrhage), tumor size, recurrence, and HE classification.
Main Results:
- All pituitary adenomas displayed VEGF immunoreactivity, primarily in the cytoplasm of tumor cells.
- A significant association was found between VEGF immunoreactivity and the presence of a cystic component.
- No significant relationship was observed between VEGF expression and hemorrhage, tumor size, recurrence, or HE classification.
Conclusions:
- VEGF expression is prevalent in pituitary adenomas.
- VEGF may play a role in the pathogenesis of cystic formation within pituitary adenomas.
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