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[Membrane-selective electrode for atropine assay].

Nela Bibire1, Gladiola Tântaru, V Dorneanu

  • 1Disciplina de Chimie analitică şi Analiză instrumentálă, Facultatea de Farmacie, Unversitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|February 6, 2004
PubMed
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A new PVC matrix electrode using atropine tetraphenylborate enables accurate atropine sulphate detection. This sensitive electrode is effective for analyzing pharmaceutical formulations.

Area of Science:

  • Analytical Chemistry
  • Electrochemistry
  • Materials Science

Context:

  • Accurate quantification of atropine sulphate is crucial for pharmaceutical quality control.
  • Development of selective and sensitive electrochemical sensors is an ongoing area of research.
  • Existing methods for atropine sulphate analysis may have limitations in sensitivity or applicability.

Purpose:

  • To develop and characterize a novel membrane-selective electrode for atropine determination.
  • To evaluate the performance of the electrode in terms of linearity, detection limit, and selectivity.
  • To demonstrate the utility of the developed electrode for the quantitative analysis of atropine sulphate in pharmaceutical formulations.

Summary:

  • A polyvinyl chloride (PVC) matrix membrane-selective electrode incorporating atropine tetraphenylborate as the electroactive material was successfully fabricated.

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  • The electrode exhibited a linear potentiometric response for atropine sulphate over a concentration range of 10(-2) to 10(-5) M.
  • A low detection limit of 3.29 x 10(-6) M was achieved, indicating high sensitivity.
  • The electrode demonstrated excellent performance for the direct potentiometric assay and potentiometric titration of atropine sulphate in real pharmaceutical samples.

    • Impact:

    • Provides a sensitive and selective electrochemical tool for atropine sulphate quantification.
    • Offers a cost-effective and potentially rapid method for pharmaceutical analysis.
    • Contributes to the advancement of ion-selective electrode technology for drug monitoring.