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FORTE: a profile-profile comparison tool for protein fold recognition
Kentaro Tomii1, Yutaka Akiyama
1Computational Biology Research Center, The National Institute of Advanced Industrial Science and Technology, Aomi Frontier Building 2-43 Aomi, 17F, Koto-ku, Tokyo 135-0064, Japan. tomii@cbrc.jp
Bioinformatics (Oxford, England)
|February 7, 2004
Summary
FORTE is a new tool for protein fold recognition. It compares protein sequences to known structures, helping researchers identify potential structural similarities and providing results via email alignments.
Area of Science:
- Structural biology
- Bioinformatics
- Computational biology
Background:
- Protein structure prediction is crucial for understanding protein function.
- Identifying structural similarities aids in functional annotation and drug discovery.
- Existing methods for protein fold recognition have limitations.
Purpose of the Study:
- To introduce FORTE, a novel profile-profile comparison tool.
- To enable users to submit protein sequences for structural similarity analysis.
- To facilitate protein fold recognition by comparing query sequences against known structures.
Main Methods:
- FORTE utilizes a profile-profile comparison approach.
- The tool accepts protein sequences as input.
- Pairwise alignments are generated to highlight structural similarities.
Main Results:
- FORTE successfully identifies potential structural similarities in proteins.
- The tool provides detailed pairwise alignments for analysis.
- Results are delivered efficiently via email.
Conclusions:
- FORTE offers a valuable resource for protein fold recognition.
- The tool enhances the exploration of structural relationships in proteins.
- FORTE aids researchers in understanding protein structure and function.