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Lymph node positive prostate cancer: long-term survival data after radical prostatectomy
Ulrike Zwergel1, Jan Lehmann, Bernd Wullich
1Department of Urology, University of Saarland, Homburg/Saar, Germany.
The Journal of Urology
|February 10, 2004
Summary
Radical prostatectomy is a viable option for prostate cancer patients with positive lymph nodes, offering good long-term survival. Many patients with lymph node metastases do not die from prostate cancer within 10 years post-surgery.
Area of Science:
- Urology
- Oncology
- Surgical Oncology
Background:
- Prostate cancer with positive regional lymph nodes presents a treatment challenge.
- Assessing long-term outcomes is crucial for treatment planning.
Purpose of the Study:
- To evaluate the outcomes of radical prostatectomy in patients with prostate cancer and positive lymph nodes.
- To determine overall, cancer-specific, and progression-free survival rates in this patient cohort.
Main Methods:
- Retrospective review of 147 men with positive lymph nodes after prostatectomy (1984-2002).
- 135 patients received androgen ablation therapy, with 88% starting within 6 weeks post-surgery.
- Survival rates (overall, cancer-specific, progression-free) were analyzed.
Main Results:
- Median follow-up was 41.9 months (up to 214 months).
- Disease progression occurred in 33.3% of patients; 24.5% died (22 from prostate cancer).
- 10-year overall survival was 60.1%, and cancer-specific survival was 73.7%.
Conclusions:
- Radical prostatectomy, with or without hormonal therapy, is a viable treatment for lymph node-positive prostate cancer.
- Long-term survival is favorable, with a significant proportion of patients not succumbing to prostate cancer within 10 years.