Related Experiment Video

Updated: Aug 13, 2026

Myocardial Infarction and Functional Outcome Assessment in Pigs
12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

Does adequate control of diabetes in the preinfarction period improve the short-term postinfarction course?

A Roth1, M Koffler, S Viskin

  • 1Department of Cardiology, Tel-Aviv Sourasky Medical Center, Israel.

Journal of Diabetes and Its Complications
|October 1, 1992
PubMed

Insights

Adequate preinfarction diabetes control did not significantly alter clinical outcomes in patients following myocardial infarction. This study found no differences in infarct size, heart failure, arrhythmias, or mortality between controlled and uncontrolled diabetic groups.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Disorders

Background:

  • Preinfarction glycemic control's impact on myocardial infarction outcomes remains unclear.
  • Diabetic patients face increased cardiovascular risk and poorer prognosis post-myocardial infarction.

Purpose of the Study:

  • To evaluate if adequate preinfarction diabetes control influences clinical outcomes in patients experiencing their first acute myocardial infarction.

Main Methods:

  • Prospective study enrolling diabetic patients with first acute myocardial infarction and a control group of non-diabetic patients.
  • Continuous monitoring of vital signs and arrhythmias, radionuclide ventriculography, and coronary balloon angioplasty when indicated.
  • Diabetes control assessed via glycosylated hemoglobin (HbA1c) levels; adequate control defined as HbA1c ≤ 8.8%.

Main Results:

  • No significant differences observed in infarct size, heart failure incidence, arrhythmias, or mortality between adequately (HbA1c 8.8 ± 0.7%) and inadequately (HbA1c 14 ± 3%) controlled diabetic patients.
  • Short-term clinical course post-myocardial infarction showed no variations based on preinfarction diabetes control status.
  • Study included 49 diabetic patients and 18 non-diabetic controls over a 1-year period with an average hospitalization of 11 days.

Conclusions:

  • Preinfarction glycemic control does not appear to significantly affect short-term clinical outcomes after acute myocardial infarction in diabetic patients.
  • Further research may be needed to explore long-term effects or different glycemic control targets.

More Related Videos

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control05:41

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control

Published on: December 16, 2022

Related Concept Videos

Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
Angina IV: Management01:26

Angina IV: Management

IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...