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Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Microwave-enhanced transition metal-catalyzed decoration of 2(1H)-pyrazinone scaffolds
Nadya Kaval1, Katalin Bisztray, Wim Dehaen
1Laboratory for Organic Synthesis, Department of Chemistry, University of Leuven, Leuven, Belgium.
Abstract:
The 2(1H)-pyrazinones have been demonstrated to be versatile building blocks for the synthesis of biologically active compounds. Here, an efficient method is described for the decoration of these interesting scaffolds. Microwave-assisted palladium catalyzed reactions allow the easy introduction of different substituents at the C3- and even at the rather unreactive C5-position of the pyrazinones. Stille, Suzuki, Heck, Sonogashira reactions, in addition to reductive dechlorinations, and cyanation reactions are investigated.
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