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Platelet adhesion onto segmented polyurethane surfaces modified by carboxybetaine
1Research Center of Surface and Interface Chemistry and Engineering Technology, Nanjing University, Nanjing 210093, PR China.
Journal of Biomaterials Science. Polymer Edition
|February 12, 2004
Summary
Researchers improved polyurethane blood compatibility by grafting carboxybetaine zwitterions onto the surface. This novel nonthrombogenic biomaterial exhibited significantly reduced platelet adhesion, enhancing hemocompatibility for demanding applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Surface Chemistry
Background:
- Polyurethanes are common blood-contacting biomaterials but require improved hemocompatibility for advanced applications.
- Surface modification is a key strategy to enhance the biocompatibility of medical materials.
Purpose of the Study:
- To synthesize a novel nonthrombogenic biomaterial by surface modification of polyurethane.
- To graft carboxybetaine zwitterions onto polyurethane films to improve blood compatibility.
Main Methods:
- A three-step surface grafting procedure was employed using hexamethylene diisocyanate (HDI), N,N-dimethylethylethanolamine (DMEA) or 4-dimethylamino-1-butanol (DMBA), and beta-propiolactone (PL).
- Surface characterization was performed using Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy (ATR-FT-IR) and X-ray Photoelectron Spectroscopy (XPS).
- Contact angle measurements and platelet adhesion tests were conducted to evaluate surface properties and hemocompatibility.
Main Results:
- The successful grafting of carboxybetaine onto the polyurethane surface was confirmed by ATR-FT-IR and XPS.
- The modified surfaces exhibited strong hydrophilicity, as indicated by contact angle measurements.
- Platelet adhesion tests demonstrated significantly reduced platelet adhesion on the carboxybetaine-grafted films, indicating good blood compatibility.
Conclusions:
- Surface modification of polyurethane with carboxybetaine zwitterions effectively creates a nonthrombogenic biomaterial.
- The enhanced hemocompatibility, characterized by low platelet adhesion, makes these modified polyurethanes suitable for more demanding blood-contacting applications.