Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Contact stimulation of cell migration.

L A Thomas1, K M Yamada

  • 1Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.

Journal of Cell Science
|December 1, 1992
PubMed
Summary

Cells migrating in dense groups, like neural crest cells, use "contact-stimulated migration." This unique behavior enhances collective cell movement and prevents dispersion, unlike isolated cells or fibroblasts.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Salivary Gland Tissue Recombination Can Modify Cell Fate.

Journal of dental research·2024
Same author

Human Bone Marrow Cell Extracts Mitigate Radiation Injury to Salivary Gland.

Journal of dental research·2022
Same author

Extracellular Matrix in Human Craniofacial Development.

Journal of dental research·2021
Same author

Single-Cell RNA-seq Identifies Cell Diversity in Embryonic Salivary Glands.

Journal of dental research·2019
Same author

Complaints about dental practitioners: an analysis of 6 years of complaints about dentists, dental prosthetists, oral health therapists, dental therapists and dental hygienists in Australia.

Australian dental journal·2018
Same author

Hyperacetylation of Microtubules in Mesenchymal Cells Increases Cytokeratin 14-Positive Epithelial Progenitors in Developing Salivary Glands.

Journal of dental research·2016

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Biophysics

Background:

  • Embryonic development involves periodic mass cell migrations.
  • Extracellular matrices facilitate cell locomotion.
  • The mechanism for cohesive migration of dense cell cohorts remains unclear.

Purpose of the Study:

  • To investigate the behavioral characteristics enabling cohesive migration of dense cell populations.
  • To identify novel mechanisms beyond extracellular matrix interactions that support collective cell movement.

Main Methods:

  • Time-lapse video microscopy was employed.
  • The migration of quail neural crest cells, human melanoma cells, and melanocytes was analyzed.
  • Cellular responses to isolation versus contact with migrating cells were compared.

Main Results:

  • Isolated cells exhibited poor or no migration.
  • Contact with migrating cells stimulated cell travel up to 200-fold, termed "contact-stimulated migration."
  • Dissociated cells ceased directional migration, preventing aberrant dispersion; fibroblasts showed minimal response.

Conclusions:

  • Contact-stimulated migration is a novel phenomenon crucial for cohesive mass cell migration.
  • This behavior activates and sustains collective cell movement, ensuring directional migration.
  • The findings offer insights into the mechanisms of embryonic cell migration and tissue formation.

Related Experiment Videos