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Updated: Aug 14, 2026

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
Published on: May 27, 2021
[An attempt to analyze lethal outcomes]
Abstract:
The results of the analysis of 2675 autopsy protocols for 1987-1990 in the Moscow City Pathology Centre and 18246 cases of surgery of patients with urgent abdominal pathology in the Ostroumov's Hospital N 33 for 1980-1989 (with 870 lethal issues) are presented. Over 62% of the total are patients over 75 years of age. The advanced age, the presence of multiple diseases (polypathies) considerably influenced the course, diagnosis, therapy and issues of diseases, particularly in the urgent surgical pathology. This is considered particularly in the urgent surgical pathology. This is considered in details on the example of the gallbladder stones. The frequency of different variants of ischemic cardiac disease, vascular brain damage, malignant tumours, respiratory diseases, diseases of the digestive and urinary tract is presented. Clinical diagnosis in cases of death at home is discussed.
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