[Adverse effects of Ferrum Lec (clinico-experimental study)]

Area of Science:

• Biochemistry
• Hematology
• Toxicology

Background:

• Iron-deficiency anemia (IDA) is a prevalent global health issue.
• Hypoxia is a common complication in severe IDA.
• Ferrum Lec is an intravenous iron preparation used for IDA treatment.

Purpose of the Study:

• To investigate the combined effects of hypoxia and Ferrum Lec in severe IDA.
• To evaluate the impact of intravenous Ferrum Lec on lysosome stability and cellular damage in IDA models.

Main Methods:

• Observational study in patients with severe IDA.
• Experimental study in rabbits with induced IDA.
• Intravenous administration of Ferrum Lec.
• Assessment of lysosomal enzyme levels in blood plasma.
• Histopathological examination of liver tissue (hepatocytes and sinusoidal cells).

Main Results:

• Intravenous Ferrum Lec treatment intensified hypoxia-induced lysosomal membrane destabilization in severe IDA.
• Significant increases in blood plasma lysosomal enzyme levels were observed.
• Development of dystrophic changes in hepatocytes and a reduction in sinusoidal cell count occurred.
• Similar negative effects were noted in both human patients and experimental rabbits.

Conclusions:

• The lysosome-tropic properties of Ferrum Lec, combined with hypoxia, can lead to significant cellular damage in severe IDA.
• Clinical practice should consider these adverse effects when administering intravenous Ferrum Lec to IDA patients.
• Further research into safer iron supplementation strategies for severe IDA is warranted.