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[Gold therapy in psoriasis arthropathica]
Summary
Gold salt therapy for psoriatic arthritis can trigger severe pustular psoriasis and leukemia. This study questions the therapeutic value of gold salts due to these serious adverse effects.
Area of Science:
- Dermatology
- Rheumatology
- Clinical Pharmacology
Context:
- Psoriatic arthritis is a chronic inflammatory condition.
- Gold salts have been used historically for treating psoriatic arthritis.
Purpose:
- To report and discuss severe adverse reactions to gold salt therapy in psoriatic arthritis patients.
- To evaluate the safety and efficacy of gold salts for psoriatic arthritis.
Summary:
- Two patients with psoriatic arthritis developed severe pustular psoriasis and a leukemic reaction after initial gold salt injections.
- The study discusses potential mechanisms for these gold-induced side effects, referencing existing literature.
Impact:
- Highlights significant risks associated with gold salt therapy in psoriatic arthritis.
- Suggests a re-evaluation of the clinical utility of gold salts for this condition.