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Intracranial granular cell tumor in a dog
Chen-Hsuan Liu1, Chen-I Liu, Sao-Ling Liang
1Department of Veterinary Medicine, National Taiwan University, Taipei 106, Taiwan, ROC.
The Journal of Veterinary Medical Science
|February 13, 2004
Summary
A canine intracranial granular cell tumor was diagnosed in a miniature poodle presenting with neurological signs. This rare brain tumor exhibited characteristic cellular morphology and immunohistochemical markers.
Area of Science:
- Veterinary Neurology
- Canine Pathology
- Neuro-oncology
Background:
- Intracranial tumors are a significant concern in veterinary medicine, particularly in older dogs.
- Granular cell tumors are rare neoplasms of uncertain lineage, with few reported cases in the central nervous system of canines.
Observation:
- A 12-year-old miniature poodle presented with a 3-month history of progressive neurological deficits.
- Magnetic resonance imaging revealed a mass in the right cerebral hemisphere causing ventricular compression.
- Necropsy identified a 2 x 3 cm white, friable mass in the right ventral pyriform lobe.
Findings:
- Microscopic examination showed large, polygonal to round cells with pale eosinophilic cytoplasm.
- Tumor cells displayed positive Periodic Acid-Schiff (PAS) staining and were immunopositive for vimentin, NSE, and S-100.
- Ultrastructural analysis revealed cytoplasmic granules and absence of a basement membrane, consistent with granular cell tumor.
Implications:
- This case contributes to the limited literature on intracranial granular cell tumors in dogs.
- Definitive diagnosis relies on a combination of imaging, histopathology, and immunohistochemistry.
- Understanding the characteristics of this rare tumor aids in accurate diagnosis and prognosis for affected animals.