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Updated: Aug 26, 2026

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
Published on: September 26, 2025
Molecular mechanisms guiding late stages of B-cell development
Antonius G Rolink1, Jan Andersson, Fritz Melchers
1Department of Molecular Immunology, Pharmazentrum, University of Basel, Basel, Switzerland. antonius.rolink@unibas.ch
Abstract:
In mice, large numbers of immature B cells are continuously produced in the bone marrow. To enter the pools of mature B cells, these immature B cells have to pass two checkpoints. First, B cells have to migrate from the bone marrow to the spleen. The second checkpoint involves the immature B cells differentiating to mature B cells within the spleen. As the net result of this selection and maturation, only a fraction of the newly produced B cells enters the mature B-cell pool. Recent advances in the understanding of the molecular mechanisms that operate at these two checkpoints are described and discussed.
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